Non-biaryl atropisomers: New classes of chiral reagents, auxiliaries, and ligands?

J. Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

155 Citations (Scopus)

Abstract

Commonly observed, but rarely exploited, is the restricted rotation about C-C single bonds inherent in certain non-biaryl compounds. Recent examples of stereoselective reactions directed by atropisomeric amides (such as that shown below) point the way to a future for these compounds as tools for asymmetric synthesis.

Original languageEnglish
Pages (from-to)949-951
Number of pages3
JournalAngewandte Chemie - International Edition
Volume36
Issue number9
DOIs
Publication statusPublished - 16 May 1997

Keywords

  • amides
  • asymmetric syntheses
  • atropisomerism
  • chirality
  • isomerism

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