Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis

Caroline F Wright, Yinghui Wei, Julian P T Higgins, Gurdeep S Sagoo

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Abstract

Cell-free fetal DNA (cffDNA) can be detected in maternal blood during pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a variety of genetic conditions. Since 1997, many studies have examined the accuracy of prenatal fetal sex determination using cffDNA, particularly for pregnancies at risk of an X-linked condition. Here we report a review and meta-analysis of the published literature to evaluate the use of cffDNA for prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science.
Original languageEnglish
Pages (from-to)476
JournalBMC Research Notes
Volume5
DOIs
Publication statusPublished - 2012

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