Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis

Caroline F Wright; Yinghui Wei; Julian P T Higgins; Gurdeep S Sagoo

doi:10.1186/1756-0500-5-476

Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis

Caroline F Wright, Yinghui Wei, Julian P T Higgins, Gurdeep S Sagoo

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

60 Citations (Scopus)

Abstract

Cell-free fetal DNA (cffDNA) can be detected in maternal blood during pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a variety of genetic conditions. Since 1997, many studies have examined the accuracy of prenatal fetal sex determination using cffDNA, particularly for pregnancies at risk of an X-linked condition. Here we report a review and meta-analysis of the published literature to evaluate the use of cffDNA for prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science.

Original language	English
Pages (from-to)	476
Journal	BMC Research Notes
Volume	5
DOIs	https://doi.org/10.1186/1756-0500-5-476
Publication status	Published - 2012

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title = "Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis",

abstract = "Cell-free fetal DNA (cffDNA) can be detected in maternal blood during pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a variety of genetic conditions. Since 1997, many studies have examined the accuracy of prenatal fetal sex determination using cffDNA, particularly for pregnancies at risk of an X-linked condition. Here we report a review and meta-analysis of the published literature to evaluate the use of cffDNA for prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science.",

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T1 - Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis

AU - Wright, Caroline F

AU - Wei, Yinghui

AU - Higgins, Julian P T

AU - Sagoo, Gurdeep S

PY - 2012

Y1 - 2012

N2 - Cell-free fetal DNA (cffDNA) can be detected in maternal blood during pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a variety of genetic conditions. Since 1997, many studies have examined the accuracy of prenatal fetal sex determination using cffDNA, particularly for pregnancies at risk of an X-linked condition. Here we report a review and meta-analysis of the published literature to evaluate the use of cffDNA for prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science.

AB - Cell-free fetal DNA (cffDNA) can be detected in maternal blood during pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a variety of genetic conditions. Since 1997, many studies have examined the accuracy of prenatal fetal sex determination using cffDNA, particularly for pregnancies at risk of an X-linked condition. Here we report a review and meta-analysis of the published literature to evaluate the use of cffDNA for prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science.

U2 - 10.1186/1756-0500-5-476

DO - 10.1186/1756-0500-5-476

M3 - Article (Academic Journal)

C2 - 22937795

SN - 1756-0500

VL - 5

SP - 476

JO - BMC Research Notes

JF - BMC Research Notes

ER -

Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis

Abstract

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