Noninvasive assessment of LV contraction patterns using CMR to identify responders to CRT

Manav Sohal, Anoop Shetty, Simon Duckett, Zhong Chen, Eva Sammut, Sana Amraoui, Gerry Carr-White, Reza Razavi, Christopher Aldo Rinaldi

Research output: Contribution to journalArticle (Academic Journal)peer-review

38 Citations (Scopus)


OBJECTIVES: Type II activation describes the U-shaped electrical activation of the left ventricle (LV) with a line of block in patients with left bundle branch block (LBBB). We sought to determine if a corresponding pattern of contraction could be identified using cardiac magnetic resonance (CMR) cine imaging and whether this predicted response to cardiac resynchronization therapy (CRT).

BACKGROUND: U-shaped LV electrical activation in LBBB has been shown to predict favorable response to CRT. It is not known if the degree of electromechanical coupling is such that the same is true for LV contraction patterns.

METHODS: A total of 52 patients (48% ischemic) scheduled for CRT implantation prospectively underwent pre-implantation CMR cine analysis using endocardial contour tracking software to generate time-volume curves and contraction propagation maps. These were analyzed to assess the contraction sequence of the LV. The effect of contraction pattern on CRT response in terms of reverse remodeling (RR) and clinical parameters (New York Heart Association functional class, 6-min walk distance and Heart Failure Questionnaire score) was assessed at 6 months.

RESULTS: Two types of contraction pattern were identified; homogenous spread from septum to lateral wall (type I, n = 27) and presence of block with a subsequent U-shaped contraction pattern (type II, n = 25). Rates of RR in those with a type 2 pattern were significantly greater at 6 months (80% vs. 26%, p < 0.001) as was mean increase in 6-min walk distance (126 ± 106 m vs. 55 ± 60 m; p = 0.004).

CONCLUSIONS: Cine CMR can identify a U-shaped pattern of contraction which predicts increased echocardiographic and clinical response rates to CRT in patients with LBBB.

Original languageEnglish
Pages (from-to)864-73
Number of pages10
JournalJACC: Cardiovascular Imaging
Issue number8
Publication statusPublished - Aug 2013

Bibliographical note

Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.


  • Aged
  • Bundle-Branch Block/diagnosis
  • Cardiac Resynchronization Therapy
  • Exercise Test
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging, Cine
  • Male
  • Middle Aged
  • Myocardial Contraction
  • Patient Selection
  • Predictive Value of Tests
  • Prospective Studies
  • Software
  • Surveys and Questionnaires
  • Treatment Outcome
  • Ventricular Function, Left
  • Ventricular Remodeling


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