Nonlinear effects of environment on childhood asthma susceptibility

Dilini Kothalawala; Veronique Weiss; Latha Kadalayil; Raquel Granell; John Curtin; John W. Holloway

doi:10.1111/pai.13777

Nonlinear effects of environment on childhood asthma susceptibility

Dilini Kothalawala, Veronique Weiss, Latha Kadalayil, Raquel Granell, John Curtin, John W. Holloway^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

2 Citations (Scopus)

64 Downloads (Pure)

Abstract

[No abstract]

Original language	English
Article number	e13777
Journal	Pediatric Allergy and Immunology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1111/pai.13777
Publication status	Published - 25 Apr 2022

Bibliographical note

Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.

Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.

Research Groups and Themes

ALSPAC

Keywords

ALSPAC
childhood asthma
meta-analysis
parental smoking
polygenic risk score,
PRS-by-environment interactions

Access to Document

10.1111/pai.13777

Full-text PDF (author accepted manuscript)
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1111/pai.13777. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 384 KBLicence: Unspecified
Supplementary information PDF
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Wiley at https://doi.org/10.1111/pai.13777. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 307 KBLicence: Unspecified

Handle.net

Persistent link

Cite this

@article{51b22dcbd7694f42a55100b5a3446f7b,

title = "Nonlinear effects of environment on childhood asthma susceptibility",

abstract = "[No abstract]",

keywords = "ALSPAC, childhood asthma, meta-analysis, parental smoking, polygenic risk score,, PRS-by-environment interactions",

author = "Dilini Kothalawala and Veronique Weiss and Latha Kadalayil and Raquel Granell and John Curtin and Holloway, {John W.}",

note = "Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z. Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.",

year = "2022",

month = apr,

day = "25",

doi = "10.1111/pai.13777",

language = "English",

volume = "33",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Munksgaard International Publishers",

number = "4",

}

TY - JOUR

T1 - Nonlinear effects of environment on childhood asthma susceptibility

AU - Kothalawala, Dilini

AU - Weiss, Veronique

AU - Kadalayil, Latha

AU - Granell, Raquel

AU - Curtin, John

AU - Holloway, John W.

N1 - Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z. Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.

PY - 2022/4/25

Y1 - 2022/4/25

N2 - [No abstract]

AB - [No abstract]

KW - ALSPAC

KW - childhood asthma

KW - meta-analysis

KW - parental smoking

KW - polygenic risk score,

KW - PRS-by-environment interactions

U2 - 10.1111/pai.13777

DO - 10.1111/pai.13777

M3 - Letter (Academic Journal)

C2 - 35470933

SN - 0905-6157

VL - 33

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 4

M1 - e13777

ER -

Nonlinear effects of environment on childhood asthma susceptibility

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

Handle.net

Fingerprint

Cite this