Nonlinear effects of environment on childhood asthma susceptibility

Dilini Kothalawala, Veronique Weiss, Latha Kadalayil, Raquel Granell, John Curtin, John W. Holloway*

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

24 Downloads (Pure)

Abstract

[No abstract]
Original languageEnglish
Article numbere13777
JournalPediatric Allergy and Immunology
Volume33
Issue number4
DOIs
Publication statusPublished - 25 Apr 2022

Bibliographical note

Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.

Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.

Structured keywords

  • ALSPAC

Keywords

  • ALSPAC
  • childhood asthma
  • meta-analysis
  • parental smoking
  • polygenic risk score,
  • PRS-by-environment interactions

Fingerprint

Dive into the research topics of 'Nonlinear effects of environment on childhood asthma susceptibility'. Together they form a unique fingerprint.

Cite this