Abstract

This paper reviews current understanding and presents new results on some of the nonlinear processes that underlie the function of the the mammalian cochlea. These processes occur within mechano-sensory hair cells that form part of the organ of Corti. After a general overview of cochlear physiology, mathematical modelling results are presented in three parts. First, the dynamic interplay between ion channels within the sensory inner hair cells is used to explain some new electrophysiological recordings from early development. Next, the state-of-the-art is reviewed in modelling the electromotility present within the outer hair cells, including the current debate concerning the role of cell body motility versus active hair bundle dynamics. A simplified model is introduced that combines both effects in order to explain observed amplification and compression in experiments. Finally, new modelling evidence is presented that structural longitudinal coupling between outer hair cells may be necessary in order to capture all features of the observed mechanical responses.
Translated title of the contributionNonlinear models of development, amplification and compression in the mammalian cochlea
Original languageEnglish
Pages (from-to)4183 - 4204
Number of pages22
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume369
Issue number1954
DOIs
Publication statusPublished - Nov 2011

Bibliographical note

Publisher: The Royal Society

Fingerprint Dive into the research topics of 'Nonlinear models of development, amplification and compression in the mammalian cochlea'. Together they form a unique fingerprint.

Cite this