Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation

Meir Lahav, Orit Uziel, Meir Kestenbaum, Abigail Fraser, Hava Shapiro, Judith Radnay, Martine Szyper-Kravitz, Shimoni Avihai, Izhar Hardan, Noga Shem-Tov, Arnon Nagler

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting "accelerated aging" of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.
Original languageEnglish
Pages (from-to)969-76
Number of pages8
JournalTransplantation
Volume80
Issue number7
Publication statusPublished - 15 Oct 2005

Keywords

  • Adolescent
  • Adult
  • Bone Marrow Transplantation
  • Cell Aging
  • DNA
  • Female
  • Graft vs Leukemia Effect
  • Humans
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Telomere
  • Tissue Donors
  • Transplantation Conditioning
  • Transplantation, Homologous

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