Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation

Meir Lahav; Orit Uziel; Meir Kestenbaum; Abigail Fraser; Hava Shapiro; Judith Radnay; Martine Szyper-Kravitz; Shimoni Avihai; Izhar Hardan; Noga Shem-Tov; Arnon Nagler

Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation

Meir Lahav
, Orit Uziel
, Meir Kestenbaum
, Abigail Fraser
, Hava Shapiro
, Judith Radnay
, Martine Szyper-Kravitz
, Shimoni Avihai
, Izhar Hardan
, Noga Shem-Tov
, Arnon Nagler

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

Abstract

Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting "accelerated aging" of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.

Original language	English
Pages (from-to)	969-76
Number of pages	8
Journal	Transplantation
Volume	80
Issue number	7
Publication status	Published - 15 Oct 2005

Keywords

Adolescent
Adult
Bone Marrow Transplantation
Cell Aging
DNA
Female
Graft vs Leukemia Effect
Humans
Leukocytes, Mononuclear
Male
Middle Aged
Telomere
Tissue Donors
Transplantation Conditioning
Transplantation, Homologous

Handle.net

Persistent link

Cite this

@article{70d38c307f1f4271ad2c1e4deaa65a55,

title = "Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation",

abstract = "Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting {"}accelerated aging{"} of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.",

keywords = "Adolescent, Adult, Bone Marrow Transplantation, Cell Aging, DNA, Female, Graft vs Leukemia Effect, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Telomere, Tissue Donors, Transplantation Conditioning, Transplantation, Homologous",

author = "Meir Lahav and Orit Uziel and Meir Kestenbaum and Abigail Fraser and Hava Shapiro and Judith Radnay and Martine Szyper-Kravitz and Shimoni Avihai and Izhar Hardan and Noga Shem-Tov and Arnon Nagler",

year = "2005",

month = oct,

day = "15",

language = "English",

volume = "80",

pages = "969--76",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

TY - JOUR

T1 - Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation

AU - Lahav, Meir

AU - Uziel, Orit

AU - Kestenbaum, Meir

AU - Fraser, Abigail

AU - Shapiro, Hava

AU - Radnay, Judith

AU - Szyper-Kravitz, Martine

AU - Avihai, Shimoni

AU - Hardan, Izhar

AU - Shem-Tov, Noga

AU - Nagler, Arnon

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting "accelerated aging" of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.

AB - Stem cell transplantation (SCT) may be associated with premature aging of the hematopoietic stem cells. Telomere length reflects the proliferative history of a cell. In most studies published so far on telomere dynamics after myeloablative allogeneic SCT, recipients had shorter telomeres than their respective donors, thus reflecting "accelerated aging" of hematopoietic cells. We evaluated telomere dynamics in patients who underwent transplantation with nonmyeloablative protocols, assuming that the decreased intensity of chemotherapy might prevent telomere attrition.

KW - Adolescent

KW - Adult

KW - Bone Marrow Transplantation

KW - Cell Aging

KW - DNA

KW - Female

KW - Graft vs Leukemia Effect

KW - Humans

KW - Leukocytes, Mononuclear

KW - Male

KW - Middle Aged

KW - Telomere

KW - Tissue Donors

KW - Transplantation Conditioning

KW - Transplantation, Homologous

M3 - Article (Academic Journal)

C2 - 16249747

SN - 0041-1337

VL - 80

SP - 969

EP - 976

JO - Transplantation

JF - Transplantation

IS - 7

ER -

Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation

Abstract

Keywords

Handle.net

Fingerprint

Cite this