Normalized handgrip strength and future risk of hypertension: findings from a prospective cohort study

Setor K Kunutsor; Timo Mäkikallio; Ari Voutilainen; David Hupin; Jari A Laukkanen

doi:10.1080/14017431.2021.1983206

Normalized handgrip strength and future risk of hypertension: findings from a prospective cohort study

Setor K Kunutsor^*, Timo Mäkikallio, Ari Voutilainen, David Hupin, Jari A Laukkanen

^*Corresponding author for this work

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Abstract

Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength was normalized (HGS/body weight2/3). After 16 years median follow-up, 110 hypertension cases occurred. Comparing the extreme tertiles of normalized HGS, the multivariable adjusted hazard ratio (95% CI) for hypertension was 0.63 (0.38-1.04). Previous evidence of associations may have been driven by study design limitations such as lack of temporality.

Original language	English
Pages (from-to)	336-339
Journal	Scandinavian Cardiovascular Journal
Volume	55
Issue number	6
Early online date	11 Oct 2021
DOIs	https://doi.org/10.1080/14017431.2021.1983206
Publication status	E-pub ahead of print - 11 Oct 2021

Keywords

handgrip strength
hypertension
risk factor
cohort study

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10.1080/14017431.2021.1983206

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Swedish Heart Association at https://doi.org/10.1080/14017431.2021.1983206. Please refer to any applicable terms of use of the publisher.
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title = "Normalized handgrip strength and future risk of hypertension: findings from a prospective cohort study",

abstract = "Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength was normalized (HGS/body weight2/3). After 16 years median follow-up, 110 hypertension cases occurred. Comparing the extreme tertiles of normalized HGS, the multivariable adjusted hazard ratio (95% CI) for hypertension was 0.63 (0.38-1.04). Previous evidence of associations may have been driven by study design limitations such as lack of temporality.",

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AU - Mäkikallio, Timo

AU - Voutilainen, Ari

AU - Hupin, David

AU - Laukkanen, Jari A

PY - 2021/10/11

Y1 - 2021/10/11

N2 - Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength was normalized (HGS/body weight2/3). After 16 years median follow-up, 110 hypertension cases occurred. Comparing the extreme tertiles of normalized HGS, the multivariable adjusted hazard ratio (95% CI) for hypertension was 0.63 (0.38-1.04). Previous evidence of associations may have been driven by study design limitations such as lack of temporality.

AB - Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength was normalized (HGS/body weight2/3). After 16 years median follow-up, 110 hypertension cases occurred. Comparing the extreme tertiles of normalized HGS, the multivariable adjusted hazard ratio (95% CI) for hypertension was 0.63 (0.38-1.04). Previous evidence of associations may have been driven by study design limitations such as lack of temporality.

KW - handgrip strength

KW - hypertension

KW - risk factor

KW - cohort study

U2 - 10.1080/14017431.2021.1983206

DO - 10.1080/14017431.2021.1983206

M3 - Article (Academic Journal)

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EP - 339

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

IS - 6

ER -

Normalized handgrip strength and future risk of hypertension: findings from a prospective cohort study

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