Normoxic and hyperoxic cardiopulmonary bypass in congenital heart disease

Amir Mokhtari, Martin Lewis

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)


Cyanotic congenital heart disease comprises a diverse spectrum of anatomical pathologies. Common to all, however, is chronic hypoxia before these lesions are operated upon when cardiopulmonary bypass is initiated. A range of functional and structural adaptations take place in the chronically hypoxic heart, which, whilst protective in the hypoxic state, are deleterious when the availability of oxygen to the myocardium is suddenly improved. Conventional cardiopulmonary bypass delivers hyperoxic perfusion to the myocardium and is associated with cardiac injury and systemic stress, whilst a normoxic perfusate protects against these insults.

Original languageEnglish
Pages (from-to)678268
JournalBioMed Research International
Publication statusPublished - 2014


  • Adaptation, Physiological
  • Cardiopulmonary Bypass/adverse effects
  • Heart Defects, Congenital/complications
  • Humans
  • Hypoxia/etiology
  • Models, Cardiovascular
  • Myocardial Reperfusion Injury/etiology


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