Normoxic and hyperoxic cardiopulmonary bypass in congenital heart disease

Amir Mokhtari, Martin Lewis

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Abstract

Cyanotic congenital heart disease comprises a diverse spectrum of anatomical pathologies. Common to all, however, is chronic hypoxia before these lesions are operated upon when cardiopulmonary bypass is initiated. A range of functional and structural adaptations take place in the chronically hypoxic heart, which, whilst protective in the hypoxic state, are deleterious when the availability of oxygen to the myocardium is suddenly improved. Conventional cardiopulmonary bypass delivers hyperoxic perfusion to the myocardium and is associated with cardiac injury and systemic stress, whilst a normoxic perfusate protects against these insults.

Original languageEnglish
Pages (from-to)678268
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Keywords

  • Adaptation, Physiological
  • Cardiopulmonary Bypass/adverse effects
  • Heart Defects, Congenital/complications
  • Humans
  • Hypoxia/etiology
  • Models, Cardiovascular
  • Myocardial Reperfusion Injury/etiology

Fingerprint Dive into the research topics of 'Normoxic and hyperoxic cardiopulmonary bypass in congenital heart disease'. Together they form a unique fingerprint.

  • Cite this