Notch signalling in ischaemia-induced angiogenesis

Ayman Al Haj Zen, Paolo Madeddu

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates several steps of the reparative process occurring in ischaemic tissues, including sprouting angiogenesis, vessel maturation, interaction of vascular cells with recruited leucocytes and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis.
Translated title of the contributionNotch signalling in ischaemia-induced angiogenesis
Original languageEnglish
Pages (from-to)1221 - 1227
Number of pages7
JournalBiochemical Society Transactions
Volume37
Issue numberPt 6
DOIs
Publication statusPublished - Dec 2009

Bibliographical note

Publisher: Biochem Soc Trans

Keywords

  • Anoxia
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Ischemia
  • Muscle, Skeletal
  • Neovascularization, Physiologic
  • Receptors, Notch
  • Regeneration
  • Signal Transduction

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