Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

Research output: Contribution to journalReview article (Academic Journal)

28 Downloads (Pure)

Abstract

During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.
Original languageEnglish
Pages (from-to)16 - 23
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume61
Early online date16 Jul 2019
DOIs
Publication statusPublished - 1 Dec 2019

Fingerprint Dive into the research topics of 'Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis'. Together they form a unique fingerprint.

  • Cite this