Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

Bethan Lloyd-Lewis

doi:10.1016/j.ceb.2019.06.003

Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis

Bethan Lloyd-Lewis

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Review article (Academic Journal)

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Abstract

During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.

Original language	English
Pages (from-to)	16 - 23
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	61
Early online date	16 Jul 2019
DOIs	https://doi.org/10.1016/j.ceb.2019.06.003
Publication status	Published - 1 Dec 2019

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10.1016/j.ceb.2019.06.003

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.06.003 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 5.67 MBLicence: CC BY-NC-ND
Fre_Fig 2
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ceb.2019.06.003 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 5.55 MBLicence: CC BY-NC-ND

http://dx.doi.org/10.1016/j.ceb.2019.06.003

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Lloyd-Lewis, B. (2019). Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis. Current Opinion in Cell Biology, 61, 16 - 23. https://doi.org/10.1016/j.ceb.2019.06.003

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