Novel Anodization Technique Using a Block Copolymer Template for Nanopatterning of Titanium Implant Surfaces

Terje Sjöström, Laura E. McNamara, Li Yang, Matthew J. Dalby, Bo Su

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Abstract

Precise surface nanopatterning is a promising route for predictable control of cellular behavior on biomedical materials. There is currently a gap in taking such precision engineered surfaces from the laboratory to clinically relevant implant materials such as titanium (Ti). In this work, anodization of Ti surfaces was performed in combination with block copolymer templates to create highly ordered and tunable oxide nanopatterns. Secondary ion mass spectroscopy (SIMS) and X-ray photoelectron spectroscopy (XPS) analyses showed that the composition of the anodized structures was mainly titania with small amounts of nitrogen left from the block copolymer. It was further demonstrated that these nanopatterns can be superimposed on more complex shaped Ti surfaces such as microbeads, using the same technique. Human mesenchymal stem cells were cultured on Ti microbead surfaces, with and without nanopatterns, in vitro to study the effect of nanotopography on Ti surfaces. The results presented in this work demonstrate a promising method of producing highly defined and well-arranged surface nanopatterns on Ti implant surfaces.

Original languageEnglish
Pages (from-to)6354-6361
Number of pages8
JournalACS Applied Materials and Interfaces
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • biomaterials
  • NANOTOPOGRAPHY
  • ADHESION
  • XPS
  • nanopatterning
  • RAY PHOTOELECTRON-SPECTROSCOPY
  • FUNCTIONALIZATION
  • block copolymers
  • anodization
  • NANOSTRUCTURES
  • stem cells
  • titanium
  • TIO2 THIN-FILMS
  • VISIBLE-LIGHT
  • ORDERED ARRAYS
  • DIBLOCK COPOLYMER

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