Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

Nicholas L Smith; Ming-Huei Chen; Abbas Dehghan; David P Strachan; Saonli Basu; Nicole Soranzo; Caroline Hayward; Igor Rudan; Maria Sabater-Lleal; Joshua C Bis; Moniek P M de Maat; Ann Rumley; Xiaoxiao Kong; Qiong Yang; Frances M K Williams; Veronique Vitart; Harry Campbell; Anders Mälarstig; Kerri L Wiggins; Cornelia M Van Duijn; Wendy L McArdle; James S Pankow; Andrew D Johnson; Angela Silveira; Barbara McKnight; Andre G Uitterlinden; Nena Aleksic; James B Meigs; Annette Peters; Wolfgang Koenig; Mary Cushman; Sekar Kathiresan; Jerome I Rotter; Edwin G Bovill; Albert Hofman; Eric Boerwinkle; Geoffrey H Tofler; John F Peden; Bruce M Psaty; Frank Leebeek; Aaron R Folsom; Martin G Larson; Timothy D Spector; Alan F Wright; James F Wilson; Anders Hamsten; Thomas Lumley; Jacqueline C M Witteman; Weihong Tang; Christopher J O'Donnell; Wellcome Trust Case Control Consortium;

doi:10.1161/CIRCULATIONAHA.109.869156

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

Nicholas L Smith, Ming-Huei Chen, Abbas Dehghan, David P Strachan, Saonli Basu, Nicole Soranzo, Caroline Hayward, Igor Rudan, Maria Sabater-Lleal, Joshua C Bis, Moniek P M de Maat, Ann Rumley, Xiaoxiao Kong, Qiong Yang, Frances M K Williams, Veronique Vitart, Harry Campbell, Anders Mälarstig, Kerri L Wiggins, Cornelia M Van DuijnWendy L McArdle, James S Pankow, Andrew D Johnson, Angela Silveira, Barbara McKnight, Andre G Uitterlinden, Nena Aleksic, James B Meigs, Annette Peters, Wolfgang Koenig, Mary Cushman, Sekar Kathiresan, Jerome I Rotter, Edwin G Bovill, Albert Hofman, Eric Boerwinkle, Geoffrey H Tofler, John F Peden, Bruce M Psaty, Frank Leebeek, Aaron R Folsom, Martin G Larson, Timothy D Spector, Alan F Wright, James F Wilson, Anders Hamsten, Thomas Lumley, Jacqueline C M Witteman, Weihong Tang, Christopher J O'Donnell, Wellcome Trust Case Control Consortium;

Research output: Contribution to journal › Article (Academic Journal) › peer-review

236 Citations (Scopus)

Abstract

Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.

Original language	English
Pages (from-to)	1382-92
Number of pages	11
Journal	Circulation
Volume	121
Issue number	12
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.109.869156
Publication status	Published - 2010

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10.1161/CIRCULATIONAHA.109.869156

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Smith, N. L., Chen, M-H., Dehghan, A., Strachan, D. P., Basu, S., Soranzo, N., Hayward, C., Rudan, I., Sabater-Lleal, M., Bis, J. C., de Maat, M. P. M., Rumley, A., Kong, X., Yang, Q., Williams, F. M. K., Vitart, V., Campbell, H., Mälarstig, A., Wiggins, K. L., ... Wellcome Trust Case Control Consortium; (2010). Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation, 121(12), 1382-92. https://doi.org/10.1161/CIRCULATIONAHA.109.869156

Smith, Nicholas L ; Chen, Ming-Huei ; Dehghan, Abbas ; Strachan, David P ; Basu, Saonli ; Soranzo, Nicole ; Hayward, Caroline ; Rudan, Igor ; Sabater-Lleal, Maria ; Bis, Joshua C ; de Maat, Moniek P M ; Rumley, Ann ; Kong, Xiaoxiao ; Yang, Qiong ; Williams, Frances M K ; Vitart, Veronique ; Campbell, Harry ; Mälarstig, Anders ; Wiggins, Kerri L ; Van Duijn, Cornelia M ; McArdle, Wendy L ; Pankow, James S ; Johnson, Andrew D ; Silveira, Angela ; McKnight, Barbara ; Uitterlinden, Andre G ; Aleksic, Nena ; Meigs, James B ; Peters, Annette ; Koenig, Wolfgang ; Cushman, Mary ; Kathiresan, Sekar ; Rotter, Jerome I ; Bovill, Edwin G ; Hofman, Albert ; Boerwinkle, Eric ; Tofler, Geoffrey H ; Peden, John F ; Psaty, Bruce M ; Leebeek, Frank ; Folsom, Aaron R ; Larson, Martin G ; Spector, Timothy D ; Wright, Alan F ; Wilson, James F ; Hamsten, Anders ; Lumley, Thomas ; Witteman, Jacqueline C M ; Tang, Weihong ; O'Donnell, Christopher J ; Wellcome Trust Case Control Consortium;. / Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor : The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. In: Circulation. 2010 ; Vol. 121, No. 12. pp. 1382-92.

@article{573ab8263ce4401090df8e7f1a3bd8c9,

title = "Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium",

abstract = "Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.",

author = "Smith, {Nicholas L} and Ming-Huei Chen and Abbas Dehghan and Strachan, {David P} and Saonli Basu and Nicole Soranzo and Caroline Hayward and Igor Rudan and Maria Sabater-Lleal and Bis, {Joshua C} and {de Maat}, {Moniek P M} and Ann Rumley and Xiaoxiao Kong and Qiong Yang and Williams, {Frances M K} and Veronique Vitart and Harry Campbell and Anders M{\"a}larstig and Wiggins, {Kerri L} and {Van Duijn}, {Cornelia M} and McArdle, {Wendy L} and Pankow, {James S} and Johnson, {Andrew D} and Angela Silveira and Barbara McKnight and Uitterlinden, {Andre G} and Nena Aleksic and Meigs, {James B} and Annette Peters and Wolfgang Koenig and Mary Cushman and Sekar Kathiresan and Rotter, {Jerome I} and Bovill, {Edwin G} and Albert Hofman and Eric Boerwinkle and Tofler, {Geoffrey H} and Peden, {John F} and Psaty, {Bruce M} and Frank Leebeek and Folsom, {Aaron R} and Larson, {Martin G} and Spector, {Timothy D} and Wright, {Alan F} and Wilson, {James F} and Anders Hamsten and Thomas Lumley and Witteman, {Jacqueline C M} and Weihong Tang and O'Donnell, {Christopher J} and {Wellcome Trust Case Control Consortium;}",

year = "2010",

doi = "10.1161/CIRCULATIONAHA.109.869156",

language = "English",

volume = "121",

pages = "1382--92",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

Smith, NL, Chen, M-H, Dehghan, A, Strachan, DP, Basu, S, Soranzo, N, Hayward, C, Rudan, I, Sabater-Lleal, M, Bis, JC, de Maat, MPM, Rumley, A, Kong, X, Yang, Q, Williams, FMK, Vitart, V, Campbell, H, Mälarstig, A, Wiggins, KL, Van Duijn, CM, McArdle, WL, Pankow, JS, Johnson, AD, Silveira, A, McKnight, B, Uitterlinden, AG, Aleksic, N, Meigs, JB, Peters, A, Koenig, W, Cushman, M, Kathiresan, S, Rotter, JI, Bovill, EG, Hofman, A, Boerwinkle, E, Tofler, GH, Peden, JF, Psaty, BM, Leebeek, F, Folsom, AR, Larson, MG, Spector, TD, Wright, AF, Wilson, JF, Hamsten, A, Lumley, T, Witteman, JCM, Tang, W, O'Donnell, CJ & Wellcome Trust Case Control Consortium; 2010, 'Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium', Circulation, vol. 121, no. 12, pp. 1382-92. https://doi.org/10.1161/CIRCULATIONAHA.109.869156

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor : The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. / Smith, Nicholas L; Chen, Ming-Huei; Dehghan, Abbas; Strachan, David P; Basu, Saonli; Soranzo, Nicole; Hayward, Caroline; Rudan, Igor; Sabater-Lleal, Maria; Bis, Joshua C; de Maat, Moniek P M; Rumley, Ann; Kong, Xiaoxiao; Yang, Qiong; Williams, Frances M K; Vitart, Veronique; Campbell, Harry; Mälarstig, Anders; Wiggins, Kerri L; Van Duijn, Cornelia M; McArdle, Wendy L; Pankow, James S; Johnson, Andrew D; Silveira, Angela; McKnight, Barbara; Uitterlinden, Andre G; Aleksic, Nena; Meigs, James B; Peters, Annette; Koenig, Wolfgang; Cushman, Mary; Kathiresan, Sekar; Rotter, Jerome I; Bovill, Edwin G; Hofman, Albert; Boerwinkle, Eric; Tofler, Geoffrey H; Peden, John F; Psaty, Bruce M; Leebeek, Frank; Folsom, Aaron R; Larson, Martin G; Spector, Timothy D; Wright, Alan F; Wilson, James F; Hamsten, Anders; Lumley, Thomas; Witteman, Jacqueline C M; Tang, Weihong; O'Donnell, Christopher J; Wellcome Trust Case Control Consortium;.

In: Circulation, Vol. 121, No. 12, 2010, p. 1382-92.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor

T2 - The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

AU - Smith, Nicholas L

AU - Chen, Ming-Huei

AU - Dehghan, Abbas

AU - Strachan, David P

AU - Basu, Saonli

AU - Soranzo, Nicole

AU - Hayward, Caroline

AU - Rudan, Igor

AU - Sabater-Lleal, Maria

AU - Bis, Joshua C

AU - de Maat, Moniek P M

AU - Rumley, Ann

AU - Kong, Xiaoxiao

AU - Yang, Qiong

AU - Williams, Frances M K

AU - Vitart, Veronique

AU - Campbell, Harry

AU - Mälarstig, Anders

AU - Wiggins, Kerri L

AU - Van Duijn, Cornelia M

AU - McArdle, Wendy L

AU - Pankow, James S

AU - Johnson, Andrew D

AU - Silveira, Angela

AU - McKnight, Barbara

AU - Uitterlinden, Andre G

AU - Aleksic, Nena

AU - Meigs, James B

AU - Peters, Annette

AU - Koenig, Wolfgang

AU - Cushman, Mary

AU - Kathiresan, Sekar

AU - Rotter, Jerome I

AU - Bovill, Edwin G

AU - Hofman, Albert

AU - Boerwinkle, Eric

AU - Tofler, Geoffrey H

AU - Peden, John F

AU - Psaty, Bruce M

AU - Leebeek, Frank

AU - Folsom, Aaron R

AU - Larson, Martin G

AU - Spector, Timothy D

AU - Wright, Alan F

AU - Wilson, James F

AU - Hamsten, Anders

AU - Lumley, Thomas

AU - Witteman, Jacqueline C M

AU - Tang, Weihong

AU - O'Donnell, Christopher J

AU - Wellcome Trust Case Control Consortium;

PY - 2010

Y1 - 2010

N2 - Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.

AB - Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.

U2 - 10.1161/CIRCULATIONAHA.109.869156

DO - 10.1161/CIRCULATIONAHA.109.869156

M3 - Article (Academic Journal)

C2 - 20231535

VL - 121

SP - 1382

EP - 1392

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 12

ER -