Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

Nicholas L Smith, Ming-Huei Chen, Abbas Dehghan, David P Strachan, Saonli Basu, Nicole Soranzo, Caroline Hayward, Igor Rudan, Maria Sabater-Lleal, Joshua C Bis, Moniek P M de Maat, Ann Rumley, Xiaoxiao Kong, Qiong Yang, Frances M K Williams, Veronique Vitart, Harry Campbell, Anders Mälarstig, Kerri L Wiggins, Cornelia M Van DuijnWendy L McArdle, James S Pankow, Andrew D Johnson, Angela Silveira, Barbara McKnight, Andre G Uitterlinden, Nena Aleksic, James B Meigs, Annette Peters, Wolfgang Koenig, Mary Cushman, Sekar Kathiresan, Jerome I Rotter, Edwin G Bovill, Albert Hofman, Eric Boerwinkle, Geoffrey H Tofler, John F Peden, Bruce M Psaty, Frank Leebeek, Aaron R Folsom, Martin G Larson, Timothy D Spector, Alan F Wright, James F Wilson, Anders Hamsten, Thomas Lumley, Jacqueline C M Witteman, Weihong Tang, Christopher J O'Donnell, Wellcome Trust Case Control Consortium;

Research output: Contribution to journalArticle (Academic Journal)peer-review

236 Citations (Scopus)

Abstract

Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.
Original languageEnglish
Pages (from-to)1382-92
Number of pages11
JournalCirculation
Volume121
Issue number12
DOIs
Publication statusPublished - 2010

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