Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits

N Maneka G De Silva, Timothy M Frayling

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)

Abstract

In the past 3 years, genome-wide association studies have identified many tens of common genetic variants associated with metabolic diseases and traits. Although much further research is needed to identify the target genes, the associations between gene variants and diseases are already providing biological insights. The purpose of this review is to update the reader with the most relevant findings, with a particular emphasis on type 2 diabetes (T2D) and glucose metabolism, and discuss some of the biological implications of the genetic findings.
Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalCurrent Opinion in Lipidology
Volume21
Issue number1
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Animals
  • Birth Weight
  • Diabetes Mellitus, Type 2
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Glucose
  • Humans
  • Insulin-Secreting Cells

Fingerprint

Dive into the research topics of 'Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits'. Together they form a unique fingerprint.

Cite this