Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

E Fava, J Dehghany, J Ouwendijk, A Müller, A Niederlein, P Verkade, M Meyer-Hermann, M Solimena

Research output: Contribution to journalArticle (Academic Journal)peer-review

43 Citations (Scopus)

Abstract

Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.
Original languageEnglish
Pages (from-to)1013-23
Number of pages11
JournalDiabetologia
Volume55
Issue number4
DOIs
Publication statusPublished - 2012

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