Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

E Fava, J Dehghany, J Ouwendijk, A Müller, A Niederlein, P Verkade, M Meyer-Hermann, M Solimena

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Abstract

Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.
Original languageEnglish
Pages (from-to)1013-23
Number of pages11
JournalDiabetologia
Volume55
Issue number4
DOIs
Publication statusPublished - 2012

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