Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

E Fava; J Dehghany; J Ouwendijk; A Müller; A Niederlein; P Verkade; M Meyer-Hermann; M Solimena

doi:10.1007/s00125-011-2438-4

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

E Fava
, J Dehghany
, J Ouwendijk
, A Müller
, A Niederlein
, P Verkade
, M Meyer-Hermann
, M Solimena

Dynamic Cell Biology

Research output: Contribution to journal › Article (Academic Journal) › peer-review

59 Citations (Scopus)

Abstract

Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.

Original language	English
Pages (from-to)	1013-23
Number of pages	11
Journal	Diabetologia
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s00125-011-2438-4
Publication status	Published - 2012

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title = "Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling",

abstract = "Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.",

author = "E Fava and J Dehghany and J Ouwendijk and A M{\"u}ller and A Niederlein and P Verkade and M Meyer-Hermann and M Solimena",

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AU - Fava, E

AU - Dehghany, J

AU - Ouwendijk, J

AU - Müller, A

AU - Niederlein, A

AU - Verkade, P

AU - Meyer-Hermann, M

AU - Solimena, M

PY - 2012

Y1 - 2012

N2 - Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.

AB - Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.

U2 - 10.1007/s00125-011-2438-4

DO - 10.1007/s00125-011-2438-4

M3 - Article (Academic Journal)

C2 - 22252472

SN - 1432-0428

VL - 55

SP - 1013

EP - 1023

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

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