Novel water soluble bis(μ-chloro) bridged Cu(II) binuclear and mononuclear complexes: Synthesis, characterization and biological evaluation

Thangavel Thirunavukkarasu, H. Puschmann, H. A. Sparkes, Karuppannan Natarajan*, V. G. Gnanasoundari

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
250 Downloads (Pure)

Abstract

A water soluble chloro bridged binuclear copper(II) complex (3) and mononuclear complex (4) have been synthesized from chloro substituted 2-oxo-1,2-dihydroquinolin-3-yl-methylene-2 hydroxybenzohydrazide 1 and 2 and CuCl2·2H2O. The structures of the complexes have been determined by single crystal X-ray diffraction. The binding interactions of the ligands and complexes with CT-DNA and protein have been evaluated by absorption and emission spectroscopic method. CT-DNA and ethidium bromide (EB) competitive studies revealed that the compounds could interact with CT-DNA through intercalation binding mode. Interactions of the compounds with BSA were also studied by UV−visible, fluorescence and synchronous fluorescence spectroscopic methods which showed that the compounds had a strong binding affinity with BSA through static quenching process. The cytotoxic effect of the compounds examined on cancer cell lines, such as A549 (lung cancer) and MCF7 (breast cancer) cell lines showed that all four compounds exhibited substantial cytotoxic activity.

Original languageEnglish
Article numbere4111
Number of pages14
JournalApplied Organometallic Chemistry
Volume32
Issue number3
Early online date16 Oct 2017
DOIs
Publication statusPublished - Mar 2018

Keywords

  • binuclear copper(II) complex
  • DNA/protein binding and cytotoxic activity
  • mononuclear copper(II) complex
  • Schiff base ligands

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