Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement

JW Dalley, TD Fryer, L Brichard, ESJ Robinson, DEH Theobald, K Lääne, Y Peña, ER Murphy, Y Shah, K Probst, I Abakumova, FI Aigbirhio, H Richards, J-C Bacon, BJ Everitt, TW Robbins

Research output: Contribution to journalArticle (Academic Journal)peer-review

855 Citations (Scopus)

Abstract

Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure. Using positron emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release. These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.
Translated title of the contributionNucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Original languageEnglish
Pages (from-to)1267 - 1270
Number of pages4
JournalScience
Volume315 (5816)
DOIs
Publication statusPublished - Mar 2007

Bibliographical note

Publisher: American Assoc. for the Advancement of Science

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