O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines

G Patsos, VJH Hebbe-Viton, C Robbe, D Masselot, R San Martin, R Greenwood, C Paraskeva, A Klein, M Graessmann, JC Michalski, T Gallagher, A Corfield

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

These studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. This was based on novel synthetic probes (O-glycosides, 2-azido-O glycosides and C-glycosides) based on GalNAc which were tested in the human colorectal cancer cell lines. Analysis (of intracellular aryl-glycan products) was achieved by MALDI and electrospray mass spectroscopy and glycosylation patterns for each inhibitor were identified
Translated title of the contributionO-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines
Original languageEnglish
Pages (from-to)382 - 398
Number of pages17
JournalGlycobiology
Volume19
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines'. Together they form a unique fingerprint.

Cite this