O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines

G Patsos; VJH Hebbe-Viton; C Robbe; D Masselot; R San Martin; R Greenwood; C Paraskeva; A Klein; M Graessmann; JC Michalski; T Gallagher; A Corfield

doi:10.1093/glycob/cwn149

O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines

G Patsos, VJH Hebbe-Viton, C Robbe, D Masselot, R San Martin, R Greenwood, C Paraskeva, A Klein, M Graessmann, JC Michalski, T Gallagher, A Corfield

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

These studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. This was based on novel synthetic probes (O-glycosides, 2-azido-O glycosides and C-glycosides) based on GalNAc which were tested in the human colorectal cancer cell lines. Analysis (of intracellular aryl-glycan products) was achieved by MALDI and electrospray mass spectroscopy and glycosylation patterns for each inhibitor were identified

Translated title of the contribution	O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines
Original language	English
Pages (from-to)	382 - 398
Number of pages	17
Journal	Glycobiology
Volume	19
DOIs	https://doi.org/10.1093/glycob/cwn149
Publication status	Published - 2009

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Patsos, G., Hebbe-Viton, VJH., Robbe, C., Masselot, D., San Martin, R., Greenwood, R., Paraskeva, C., Klein, A., Graessmann, M., Michalski, JC., Gallagher, T., & Corfield, A. (2009). O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines. Glycobiology, 19, 382 - 398. https://doi.org/10.1093/glycob/cwn149

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title = "O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines",

abstract = "These studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. This was based on novel synthetic probes (O-glycosides, 2-azido-O glycosides and C-glycosides) based on GalNAc which were tested in the human colorectal cancer cell lines. Analysis (of intracellular aryl-glycan products) was achieved by MALDI and electrospray mass spectroscopy and glycosylation patterns for each inhibitor were identified",

author = "G Patsos and VJH Hebbe-Viton and C Robbe and D Masselot and \{San Martin\}, R and R Greenwood and C Paraskeva and A Klein and M Graessmann and JC Michalski and T Gallagher and A Corfield",

year = "2009",

doi = "10.1093/glycob/cwn149",

language = "English",

volume = "19",

pages = "382 -- 398",

journal = "Glycobiology",

issn = "1460-2423",

publisher = "Oxford University Press",

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TY - JOUR

T1 - O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines

AU - Patsos, G

AU - Hebbe-Viton, VJH

AU - Robbe, C

AU - Masselot, D

AU - San Martin, R

AU - Greenwood, R

AU - Paraskeva, C

AU - Klein, A

AU - Graessmann, M

AU - Michalski, JC

AU - Gallagher, T

AU - Corfield, A

PY - 2009

Y1 - 2009

N2 - These studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. This was based on novel synthetic probes (O-glycosides, 2-azido-O glycosides and C-glycosides) based on GalNAc which were tested in the human colorectal cancer cell lines. Analysis (of intracellular aryl-glycan products) was achieved by MALDI and electrospray mass spectroscopy and glycosylation patterns for each inhibitor were identified

AB - These studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. This was based on novel synthetic probes (O-glycosides, 2-azido-O glycosides and C-glycosides) based on GalNAc which were tested in the human colorectal cancer cell lines. Analysis (of intracellular aryl-glycan products) was achieved by MALDI and electrospray mass spectroscopy and glycosylation patterns for each inhibitor were identified

U2 - 10.1093/glycob/cwn149

DO - 10.1093/glycob/cwn149

M3 - Article (Academic Journal)

C2 - 19122213

SN - 1460-2423

VL - 19

SP - 382

EP - 398

JO - Glycobiology

JF - Glycobiology

ER -

O-Glycan Inhibitors Generate Aryl-glycans Induce Apoptosis and Lead to Growth Inhibition in Colorectal Cancer Cell Lines

Abstract

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