O-Glycan regulation of apoptosis and proliferation in colorectal cancer cell lines

G Patsos, C Robbe-Masselot, A Klein, VJH Hebbe-Viton, R San Martin, D Masselot, M Graessmann, C Paraskeva, T Gallagher, A Corfield

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)

Abstract

Cell growth pathways are mediated through protein-glycan interactions including O-glycosylation. Investigation of these growth pathways can be carried out using appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl-O-N-acetyl-D-galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation of intracellular aryl-glycans and changes in related genes as detected by gene array. Colorectal cancer cell lines susceptible to the inhibitors showed growth arrest with all compounds. However, a differential action of each inhibitor was detected in the pattern of genes affected and in the structure of aryl-glycans formed.
Translated title of the contributionO-Glycan regulation of apoptosis and proliferation in colorectal cancer cell lines
Original languageEnglish
Pages (from-to)1372 - 1374
Number of pages3
JournalBiochemical Society Transactions
Volume35 (5)
DOIs
Publication statusPublished - Nov 2007

Bibliographical note

Publisher: Portland Press Ltd

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