Objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals

Ulf Ekelund, Soren Brage, Simon J Griffin, Nicholas J Wareham, ProActive UK Research Group, William Hollingworth

Research output: Contribution to journalArticle (Academic Journal)peer-review

113 Citations (Scopus)

Abstract

OBJECTIVE: Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at light-intensity activity, and at moderate- and vigorous-intensity physical activity (MVPA) with insulin resistance.

RESEARCH DESIGN AND METHODS: In 192 individuals (81 men and 111 women) with a family history of type 2 diabetes, we measured physical activity and anthropometric and metabolic variables at baseline and after 1 year of follow-up in the ProActive UK trial. Physical activity was measured objectively by accelerometry. Insulin resistance was expressed as fasting insulin and the homeostasis model assessment score (HOMA-IR).

RESULTS: Baseline MVPA was a significant predictor of fasting insulin at follow-up (beta = -0.004 [95% CI -0.007 to -0.0001], P = 0.022), and the association approached significance for HOMA-IR (beta = -0.003 [-0.007 to 0.000002], P = 0.052), independent of time spent sedentary, at light-intensity activity, sex, age, smoking status, waist circumference, and self-reported TV viewing. Time spent sedentary and at light-intensity activity were not significantly associated with insulin resistance. The change in MVPA between baseline and follow-up was inversely related to fasting insulin (beta = -0.003 [-0.007 to -0.0003], P = 0.032) and the HOMA-IR score (beta = -0.004 [-0.008 to -0.001], P = 0.015) at follow-up, after adjustment for baseline phenotype in addition to the same confounders as above.

CONCLUSIONS: These results highlight the importance of promoting moderate-intensity activity such as brisk walking for improving insulin sensitivity and possibly other metabolic risk factors to prevent type 2 diabetes.

Original languageEnglish
Pages (from-to)1081-6
Number of pages6
JournalDiabetes Care
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Adipose Tissue
  • Aging
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • Evidence-Based Medicine
  • Exercise
  • Family
  • Female
  • Humans
  • Insulin
  • Insulin Resistance
  • Life Style
  • Male
  • Motor Activity
  • Predictive Value of Tests
  • Rest
  • Risk Factors
  • Smoking
  • Television
  • Waist Circumference

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