Observation of a rectangular columnar phase in a DNA-calcium-zwitterionic lipid complex

Jennifer J. McManus, Joachim O. Rädler, Kenneth A. Dawson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

64 Citations (Scopus)

Abstract

In the presence of calcium, DNA and unilamellar liposomes of the zwitterionic lipid DPPC form a complex in which DNA strands are embedded between a lamellar phase of DPPC. In some complexes, in-plane alignment of the DNA strands occurs, where a DNA-DNA interaxial distance can be measured using small-angle X-ray scattering. Here we report a higher level of DNA organization, with a rectangular columnar phase of DNA identified within this complex structure. This observation is important in view of recent interests in creating new synthetic systems at the interface of biology.

Original languageEnglish
Pages (from-to)15966-15967
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number49
DOIs
Publication statusPublished - 15 Dec 2004

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