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Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

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Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection. / Al-Salem, Waleed; Solórzano, Carla; Weedall, Gareth; Dyer, Naomi; Kelly-Hope, Louise; Casas‑Sánchez, Aitor; Alraey, Yasser; Alyamani, Essam ; Halliday, Alice; Balghonaim, Salah; Alsohibany, Khalid; Alzeyadi, Zeyad; Alzahrani, Mohamed; Al-Shahrani, Ali; Assiri, Abdullah; Memish, Ziad; Acosta-Serrano, Alvaro .

In: Parasites and Vectors, Vol. 12, No. 1, 195, 02.05.2019.

Research output: Contribution to journalArticle

Harvard

Al-Salem, W, Solórzano, C, Weedall, G, Dyer, N, Kelly-Hope, L, Casas‑Sánchez, A, Alraey, Y, Alyamani, E, Halliday, A, Balghonaim, S, Alsohibany, K, Alzeyadi, Z, Alzahrani, M, Al-Shahrani, A, Assiri, A, Memish, Z & Acosta-Serrano, A 2019, 'Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection', Parasites and Vectors, vol. 12, no. 1, 195. https://doi.org/10.1186/s13071-019-3453-4

APA

Al-Salem, W., Solórzano, C., Weedall, G., Dyer, N., Kelly-Hope, L., Casas‑Sánchez, A., ... Acosta-Serrano, A. (2019). Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection. Parasites and Vectors, 12(1), [195]. https://doi.org/10.1186/s13071-019-3453-4

Vancouver

Al-Salem W, Solórzano C, Weedall G, Dyer N, Kelly-Hope L, Casas‑Sánchez A et al. Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection. Parasites and Vectors. 2019 May 2;12(1). 195. https://doi.org/10.1186/s13071-019-3453-4

Author

Al-Salem, Waleed ; Solórzano, Carla ; Weedall, Gareth ; Dyer, Naomi ; Kelly-Hope, Louise ; Casas‑Sánchez, Aitor ; Alraey, Yasser ; Alyamani, Essam ; Halliday, Alice ; Balghonaim, Salah ; Alsohibany, Khalid ; Alzeyadi, Zeyad ; Alzahrani, Mohamed ; Al-Shahrani, Ali ; Assiri, Abdullah ; Memish, Ziad ; Acosta-Serrano, Alvaro . / Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection. In: Parasites and Vectors. 2019 ; Vol. 12, No. 1.

Bibtex

@article{55659b84b4634474893f84bf1b6d95a6,
title = "Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection",
abstract = "Background: In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1{\%} clotrimazole/2{\%} fusidic acid cream followed by 1-2 courses of intralesional sodium stibogluconate (SSG); however, treatment efficacy is highly variable and the reasons for this are not well understood. In this study, we present a complete epidemiological map of CL and determined the efficacy of the standard CL treatment regime in several endemic regions of KSA. Results: Overall, three quarters of patients in all CL-endemic areas studied responded satisfactorily to the current treatment regime, with the remaining requiring only an extra course of SSG. The majority of unresponsive cases were infected with L. tropica. Furthermore, the development of secondary infections (SI) around or within the CL lesion significantly favoured the treatment response of L. major patients but had no effect on L. tropica cases. Conclusions: The response of CL patients to a national treatment protocol appears to depend on several factors, including Leishmania parasite species, geographical location and occurrences of SI. Our findings suggest there is a need to implement alternative CL treatment protocols based on these parameters.",
keywords = "Cutaneous leishmaniasis, Epidemiology, Saudi Arabia, Secondary infections, Treatment response",
author = "Waleed Al-Salem and Carla Sol{\'o}rzano and Gareth Weedall and Naomi Dyer and Louise Kelly-Hope and Aitor Casas‑S{\'a}nchez and Yasser Alraey and Essam Alyamani and Alice Halliday and Salah Balghonaim and Khalid Alsohibany and Zeyad Alzeyadi and Mohamed Alzahrani and Ali Al-Shahrani and Abdullah Assiri and Ziad Memish and Alvaro Acosta-Serrano",
year = "2019",
month = "5",
day = "2",
doi = "10.1186/s13071-019-3453-4",
language = "English",
volume = "12",
journal = "Parasites and Vectors",
issn = "1756-3305",
publisher = "BioMed Central",
number = "1",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

AU - Al-Salem, Waleed

AU - Solórzano, Carla

AU - Weedall, Gareth

AU - Dyer, Naomi

AU - Kelly-Hope, Louise

AU - Casas‑Sánchez, Aitor

AU - Alraey, Yasser

AU - Alyamani, Essam

AU - Halliday, Alice

AU - Balghonaim, Salah

AU - Alsohibany, Khalid

AU - Alzeyadi, Zeyad

AU - Alzahrani, Mohamed

AU - Al-Shahrani, Ali

AU - Assiri, Abdullah

AU - Memish, Ziad

AU - Acosta-Serrano, Alvaro

PY - 2019/5/2

Y1 - 2019/5/2

N2 - Background: In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1% clotrimazole/2% fusidic acid cream followed by 1-2 courses of intralesional sodium stibogluconate (SSG); however, treatment efficacy is highly variable and the reasons for this are not well understood. In this study, we present a complete epidemiological map of CL and determined the efficacy of the standard CL treatment regime in several endemic regions of KSA. Results: Overall, three quarters of patients in all CL-endemic areas studied responded satisfactorily to the current treatment regime, with the remaining requiring only an extra course of SSG. The majority of unresponsive cases were infected with L. tropica. Furthermore, the development of secondary infections (SI) around or within the CL lesion significantly favoured the treatment response of L. major patients but had no effect on L. tropica cases. Conclusions: The response of CL patients to a national treatment protocol appears to depend on several factors, including Leishmania parasite species, geographical location and occurrences of SI. Our findings suggest there is a need to implement alternative CL treatment protocols based on these parameters.

AB - Background: In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1% clotrimazole/2% fusidic acid cream followed by 1-2 courses of intralesional sodium stibogluconate (SSG); however, treatment efficacy is highly variable and the reasons for this are not well understood. In this study, we present a complete epidemiological map of CL and determined the efficacy of the standard CL treatment regime in several endemic regions of KSA. Results: Overall, three quarters of patients in all CL-endemic areas studied responded satisfactorily to the current treatment regime, with the remaining requiring only an extra course of SSG. The majority of unresponsive cases were infected with L. tropica. Furthermore, the development of secondary infections (SI) around or within the CL lesion significantly favoured the treatment response of L. major patients but had no effect on L. tropica cases. Conclusions: The response of CL patients to a national treatment protocol appears to depend on several factors, including Leishmania parasite species, geographical location and occurrences of SI. Our findings suggest there is a need to implement alternative CL treatment protocols based on these parameters.

KW - Cutaneous leishmaniasis

KW - Epidemiology

KW - Saudi Arabia

KW - Secondary infections

KW - Treatment response

UR - http://www.scopus.com/inward/record.url?scp=85065255632&partnerID=8YFLogxK

U2 - 10.1186/s13071-019-3453-4

DO - 10.1186/s13071-019-3453-4

M3 - Article

VL - 12

JO - Parasites and Vectors

JF - Parasites and Vectors

SN - 1756-3305

IS - 1

M1 - 195

ER -