Olefin cross-metathesis for the synthesis of heteroaromatic compounds

Timothy J. Donohoe, John F. Bower, Louis K. M. Chan

Research output: Contribution to journalArticle (Academic Journal)peer-review

63 Citations (Scopus)


The olefin metathesis reaction has underpinned spectacular achievements in organic synthesis in recent years. Arguably, metathesis has now become the foremost choice for a carbon-carbon double bond disconnection. Despite this general utility, de novo routes to heteroaromatic compounds using the cross-metathesis (CM) reaction have only recently emerged as an efficient strategy. This approach allows a convergent union of simple, functionalised, three- to four-carbon olefinic core building blocks, to generate furans, pyrroles and pyridines with a high degree of control of substitution pattern in the product.

Original languageEnglish
Pages (from-to)1322-1328
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number7
Publication statusPublished - 2012


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