ONO pincer type of palladium(II) complexes of heterocyclic hydrazone: Synthesis, characterization and biological evaluation: Synthesis, characterization and biological evaluation

Thangavel Thirunavukkarasu, Hazel A. Sparkes, Karuppannan Natarajan*, V. G. Gnanasoundari

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
160 Downloads (Pure)

Abstract

Two new Pd(II) complexes of N′-(4-(diethylamino)-2-hydroxybenzylidene)furan-2-carbohydrazide were synthesized and characterized using various spectral methods. The structure of one of the complexes was determined using single-crystal X-ray diffraction. DNA and protein binding affinities of the synthesized compounds were examined using UV–visible and fluorescence titration method. In addition, the in vitro cytotoxicity of the compounds was evaluated against A549 (lung cancer) and MCF7 (breast cancer) cell lines using the MTT assay method.
Original languageEnglish
Article numbere4403
Number of pages11
JournalApplied Organometallic Chemistry
Volume32
Issue number8
Early online date25 Jun 2018
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • cytotoxicity
  • DNA/protein binding
  • Pd(II) complexes
  • Schiff base ligand

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