Opportunities and challenges for the discovery and validation of biomarkers for common arthritic diseases

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Abstract

Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most prevalent of all the rheumatic diseases and currently, there are no reliable biochemical measures for early diagnosis or predicting who is likely to progress. Early diagnosis is important for making decisions on treatment options and for better management of patients. This narrative review highlights the first-generation biomarkers identified over the last 2 decades and focuses on the discovery and validation of candidate OA biomarkers from recent mass spectrometry-based proteomic studies for diagnosis and monitoring disease outcomes in human. It discusses the challenges and opportunities for discovery of novel biomarkers, progress in the development of techniques for measuring biomarkers, and provide directions for future discovery and validation of biomarkers for OA and RA.
Original languageEnglish
JournalBiomarkers in Medicine
Early online date4 Oct 2017
DOIs
Publication statusE-pub ahead of print - 4 Oct 2017

Keywords

  • Biomarkers
  • Proteomics
  • Mass Spectrometry
  • Osteoarthritis
  • Rheumatoid Arthritis

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