Opportunities and priorities for breast surgical research

Ramsey Cutress, Stuart McIntosh, Shelley Potter, Amit Goyal, Cliona Kirwan, James Harvey, Adele Francis, Amtul Carmichael, Raghavan Vidya, Jayant Vaidya, Patricia Fairbrother, John Benson, Malcolm Reed, the Association of Breast Surgery Surgical Gap Analysis Working Group

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)
249 Downloads (Pure)

Abstract

The 2013 Breast Cancer Campaign gap analysis established breast cancer research priorities without a specific focus on surgical research or the role of surgeons on breast cancer research. This Review aims to identify opportunities and priorities for research in breast surgery to complement the 2013 gap analysis. To identify these goals, research-active breast surgeons met and identified areas for breast surgery research that mapped to the patient pathway. Areas included diagnosis, neoadjuvant treatment, surgery, adjuvant therapy, and attention to special groups (eg, those receiving risk-reducing surgery). Section leads were identified based on research interests, with invited input from experts in specific areas, supported by consultation with members of the Association of Breast Surgery and Independent Cancer Patients' Voice groups. The document was iteratively modified until participants were satisfied that key priorities for surgical research were clear. Key research gaps included issues surrounding overdiagnosis and treatment; optimising treatment options and their selection for neoadjuvant therapies and subsequent surgery; reducing rates of re-operations for breast-conserving surgery; generating evidence for clinical effectiveness and cost-effectiveness of breast reconstruction, and mechanisms for assessing novel interventions; establishing optimal axillary management, especially post-neoadjuvant treatment; and defining and standardising indications for risk-reducing surgery. We propose strategies for resolving these knowledge gaps. Surgeons are ideally placed for a central role in breast cancer research and should foster a culture of engagement and participation in research to benefit patients and health-care systems. Development of infrastructure and surgical research capacity, together with appropriate allocation of research funding, is needed to successfully address the key clinical and translational research gaps that are highlighted in this Review within the next two decades.
Original languageEnglish
Pages (from-to)e521-e533
Number of pages13
JournalLancet Oncology
Volume19
Issue number10
Early online date1 Oct 2018
DOIs
Publication statusPublished - Oct 2018

Structured keywords

  • Centre for Surgical Research

Keywords

  • Breast cancer
  • surgery
  • review
  • gap analysis

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    Cutress, R., McIntosh, S., Potter, S., Goyal, A., Kirwan, C., Harvey, J., Francis, A., Carmichael, A., Vidya, R., Vaidya, J., Fairbrother, P., Benson, J., Reed, M., & the Association of Breast Surgery Surgical Gap Analysis Working Group (2018). Opportunities and priorities for breast surgical research. Lancet Oncology, 19(10), e521-e533. https://doi.org/10.1016/S1470-2045(18)30511-4