Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

D Baddeley, I D Jayasinghe, L Lam, S Rossberger, MB Cannell, C Soeller

Research output: Contribution to journalArticle (Academic Journal)

191 Citations (Scopus)

Abstract

We have applied an optical super-resolution technique based on single-molecule localization to examine the peripheral distribution of a cardiac signaling protein, the ryanodine receptor (RyR), in rat ventricular myocytes. RyRs form clusters with a mean size of approximately 14 RyRs per cluster, which is almost an order of magnitude smaller than previously estimated. Clusters were typically not circular (as previously assumed) but elongated with an average aspect ratio of 1.9. Edge-to-edge distances between adjacent RyR clusters were often
Original languageEnglish
Pages (from-to)22275 - 22280
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number52
DOIs
Publication statusPublished - Dec 2009

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