Optimization of the Mizoroki-Heck reaction using design of experiment (DoE)

VK Aggarwal*, AC Staubitz, Martin Owen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Abstract

The influence of the variables concentration, temperature, time, and amounts of base and palladium on the yield of a Heck reaction was investigated using statistical methods (DoE) in a systematic sequential study. This revealed that temperature, concentration, and amount of palladium were the most important variables with a factor interaction between temperature and concentration. Through this approach, the yield of the Heck reaction was improved from 57% to 98% (89% isolated) with concomitant reduction of palladium loading from 3% to 0.5%.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalOrganic Process Research & Development
Volume10
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • FREE PALLADIUM
  • CATALYST

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