Optimizing CRISPR methodology for precise gene editing in the erythroid cell line BEL-A with high efficiency generation of a sickle cell anemia model

Deborah E Daniels; Joeseph Hawksworth; Sara El Hoss; Fatima O Oyawoye; Ivan Ferrer-Vicens; Marieangela C Wilson; Jan Frayne

doi:10.3324/haematol.2024.287221

Optimizing CRISPR methodology for precise gene editing in the erythroid cell line BEL-A with high efficiency generation of a sickle cell anemia model

Deborah E Daniels
, Joeseph Hawksworth
, Sara El Hoss
, Fatima O Oyawoye
, Ivan Ferrer-Vicens
, Marieangela C Wilson
, Jan Frayne^*

^*Corresponding author for this work

Bristol Doctoral College

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

1 Citation (Scopus)

Abstract

[No abstract]

Original language	English
Pages (from-to)	2806-2811
Number of pages	6
Journal	Haematologica
Volume	110
Issue number	11
Early online date	10 Apr 2025
DOIs	https://doi.org/10.3324/haematol.2024.287221
Publication status	Published - 1 Nov 2025

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Bristol BioDesign Institute

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10.3324/haematol.2024.287221Licence: CC BY

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@article{c30e3b35542e4369a2cb9afb06358dab,

title = "Optimizing CRISPR methodology for precise gene editing in the erythroid cell line BEL-A with high efficiency generation of a sickle cell anemia model",

abstract = "[No abstract]",

author = "Daniels, \{Deborah E\} and Joeseph Hawksworth and \{El Hoss\}, Sara and Oyawoye, \{Fatima O\} and Ivan Ferrer-Vicens and Wilson, \{Marieangela C\} and Jan Frayne",

year = "2025",

month = nov,

day = "1",

doi = "10.3324/haematol.2024.287221",

language = "English",

volume = "110",

pages = "2806--2811",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "11",

}

TY - JOUR

T1 - Optimizing CRISPR methodology for precise gene editing in the erythroid cell line BEL-A with high efficiency generation of a sickle cell anemia model

AU - Daniels, Deborah E

AU - Hawksworth, Joeseph

AU - El Hoss, Sara

AU - Oyawoye, Fatima O

AU - Ferrer-Vicens, Ivan

AU - Wilson, Marieangela C

AU - Frayne, Jan

PY - 2025/11/1

Y1 - 2025/11/1

N2 - [No abstract]

AB - [No abstract]

U2 - 10.3324/haematol.2024.287221

DO - 10.3324/haematol.2024.287221

M3 - Letter (Academic Journal)

C2 - 40207730

SN - 0390-6078

VL - 110

SP - 2806

EP - 2811

JO - Haematologica

JF - Haematologica

IS - 11

ER -

Optimizing CRISPR methodology for precise gene editing in the erythroid cell line BEL-A with high efficiency generation of a sickle cell anemia model

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