Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity

Kieran M Holmes-Martin; Faezeh Arab Hassani

doi:10.1109/BioCAS61083.2024.10798369

Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity

Kieran M Holmes-Martin, Faezeh Arab Hassani

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

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Abstract

Capturing bladder muscle activities via electromyography (EMG) poses challenges. This study explores the viability of flexible organic electrochemical transistors (OECTs) as a potential alternative for real-time monitoring of ion fluxes in bladder smooth muscle function, offering a more viable solution. By optimising OECT channel dimensions and conducting in vitro characterisations, insights into device behaviour and sensitivity to ion concentrations are gained. Here, OECTs are optimised to channel dimensions with a width of 300μ m and length of 50μ m that are sensitive to ionic concentrations as low as 10μM. These results demonstrate that OECTs can provide valuable insights into smooth muscle activity and hold promise for applications in physiological research and clinical diagnostics.

Original language	English
Title of host publication	2024 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Number of pages	5
ISBN (Electronic)	9798350354959
ISBN (Print)	9798350354966
DOIs	https://doi.org/10.1109/BioCAS61083.2024.10798369
Publication status	Published - 23 Dec 2024

Publication series

Name	IEEE Biomedical Circuits and Systems (BIOCAS)
Publisher	IEEE
ISSN (Print)	2163-4025
ISSN (Electronic)	2766-4465

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10.1109/BioCAS61083.2024.10798369

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This is the accepted author manuscript (AAM) of the article which has been made Open Access under the University of Bristol's Scholarly Works Policy. The final published version (Version of Record) can be found on the publisher's website. The copyright of any third-party content, such as images, remains with the copyright holder.
Accepted author manuscript, 2.67 MBLicence: CC BY

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Holmes-Martin, K. M., & Arab Hassani, F. (2024). Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity. In 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS) (IEEE Biomedical Circuits and Systems (BIOCAS)). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/BioCAS61083.2024.10798369

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title = "Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity",

abstract = "Capturing bladder muscle activities via electromyography (EMG) poses challenges. This study explores the viability of flexible organic electrochemical transistors (OECTs) as a potential alternative for real-time monitoring of ion fluxes in bladder smooth muscle function, offering a more viable solution. By optimising OECT channel dimensions and conducting in vitro characterisations, insights into device behaviour and sensitivity to ion concentrations are gained. Here, OECTs are optimised to channel dimensions with a width of 300μ m and length of 50μ m that are sensitive to ionic concentrations as low as 10μM. These results demonstrate that OECTs can provide valuable insights into smooth muscle activity and hold promise for applications in physiological research and clinical diagnostics.",

author = "Holmes-Martin, {Kieran M} and {Arab Hassani}, Faezeh",

year = "2024",

month = dec,

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doi = "10.1109/BioCAS61083.2024.10798369",

language = "English",

isbn = "9798350354966",

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Holmes-Martin, KM & Arab Hassani, F 2024, Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity. in 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE Biomedical Circuits and Systems (BIOCAS), Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/BioCAS61083.2024.10798369

Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity. / Holmes-Martin, Kieran M ; Arab Hassani, Faezeh.
2024 IEEE Biomedical Circuits and Systems Conference (BioCAS). Institute of Electrical and Electronics Engineers (IEEE), 2024. (IEEE Biomedical Circuits and Systems (BIOCAS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

TY - GEN

T1 - Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity

AU - Holmes-Martin, Kieran M

AU - Arab Hassani, Faezeh

PY - 2024/12/23

Y1 - 2024/12/23

N2 - Capturing bladder muscle activities via electromyography (EMG) poses challenges. This study explores the viability of flexible organic electrochemical transistors (OECTs) as a potential alternative for real-time monitoring of ion fluxes in bladder smooth muscle function, offering a more viable solution. By optimising OECT channel dimensions and conducting in vitro characterisations, insights into device behaviour and sensitivity to ion concentrations are gained. Here, OECTs are optimised to channel dimensions with a width of 300μ m and length of 50μ m that are sensitive to ionic concentrations as low as 10μM. These results demonstrate that OECTs can provide valuable insights into smooth muscle activity and hold promise for applications in physiological research and clinical diagnostics.

AB - Capturing bladder muscle activities via electromyography (EMG) poses challenges. This study explores the viability of flexible organic electrochemical transistors (OECTs) as a potential alternative for real-time monitoring of ion fluxes in bladder smooth muscle function, offering a more viable solution. By optimising OECT channel dimensions and conducting in vitro characterisations, insights into device behaviour and sensitivity to ion concentrations are gained. Here, OECTs are optimised to channel dimensions with a width of 300μ m and length of 50μ m that are sensitive to ionic concentrations as low as 10μM. These results demonstrate that OECTs can provide valuable insights into smooth muscle activity and hold promise for applications in physiological research and clinical diagnostics.

U2 - 10.1109/BioCAS61083.2024.10798369

DO - 10.1109/BioCAS61083.2024.10798369

M3 - Conference Contribution (Conference Proceeding)

SN - 9798350354966

T3 - IEEE Biomedical Circuits and Systems (BIOCAS)

BT - 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS)

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

Organic Electrochemical Transistor (OECT)-based Ion Detection for Monitoring Smooth Muscle Electrical Activity

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