Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies

GM Keegan, ID Learmonth, CP Case

Research output: Contribution to journalArticle (Academic Journal)peer-review

233 Citations (Scopus)

Abstract

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.
Translated title of the contributionOrthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies
Original languageEnglish
Pages (from-to)567 - 573
Number of pages7
JournalJournal of Bone and Joint Surgery
Volume89 (5)
DOIs
Publication statusPublished - May 2007

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