Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

Gul Zaman, Helen L Jessop, Mariusz Muzylak, Roberto L De Souza, Andrew A Pitsillides, Joanna S Price, Lance L Lanyon

Research output: Contribution to journalArticle (Academic Journal)

115 Citations (Scopus)

Abstract

The role of mechanical strain and estrogen status in regulating ERalpha levels in bone cells was studied in female rats. OVX is associated with decreased ERalpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.
Original languageEnglish
Pages (from-to)1297-306
Number of pages10
JournalJournal of Bone and Mineral Research
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Active Transport, Cell Nucleus
  • Animals
  • Cells, Cultured
  • Estrogen Receptor alpha
  • Estrogens
  • Female
  • Osteoblasts
  • Osteocytes
  • Ovariectomy
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Stress, Mechanical
  • Tibia
  • Ulna

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