Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

Gul Zaman; Helen L Jessop; Mariusz Muzylak; Roberto L De Souza; Andrew A Pitsillides; Joanna S Price; Lance L Lanyon

doi:10.1359/jbmr.060504

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

Gul Zaman
, Helen L Jessop
, Mariusz Muzylak
, Roberto L De Souza
, Andrew A Pitsillides
, Joanna S Price
, Lance L Lanyon

Research output: Contribution to journal › Article (Academic Journal) › peer-review

135 Citations (Scopus)

Abstract

The role of mechanical strain and estrogen status in regulating ERalpha levels in bone cells was studied in female rats. OVX is associated with decreased ERalpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.

Original language	English
Pages (from-to)	1297-306
Number of pages	10
Journal	Journal of Bone and Mineral Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1359/jbmr.060504
Publication status	Published - Aug 2006

Keywords

Active Transport, Cell Nucleus
Animals
Cells, Cultured
Estrogen Receptor alpha
Estrogens
Female
Osteoblasts
Osteocytes
Ovariectomy
Promoter Regions, Genetic
RNA, Messenger
Rats
Rats, Sprague-Dawley
Stress, Mechanical
Tibia
Ulna

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@article{192bd9fbd30b4ef7b0a2bc18fd0f35ea,

title = "Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen",

abstract = "The role of mechanical strain and estrogen status in regulating ERalpha levels in bone cells was studied in female rats. OVX is associated with decreased ERalpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.",

keywords = "Active Transport, Cell Nucleus, Animals, Cells, Cultured, Estrogen Receptor alpha, Estrogens, Female, Osteoblasts, Osteocytes, Ovariectomy, Promoter Regions, Genetic, RNA, Messenger, Rats, Rats, Sprague-Dawley, Stress, Mechanical, Tibia, Ulna",

author = "Gul Zaman and Jessop, \{Helen L\} and Mariusz Muzylak and \{De Souza\}, \{Roberto L\} and Pitsillides, \{Andrew A\} and Price, \{Joanna S\} and Lanyon, \{Lance L\}",

year = "2006",

month = aug,

doi = "10.1359/jbmr.060504",

language = "English",

volume = "21",

pages = "1297--306",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

AU - Zaman, Gul

AU - Jessop, Helen L

AU - Muzylak, Mariusz

AU - De Souza, Roberto L

AU - Pitsillides, Andrew A

AU - Price, Joanna S

AU - Lanyon, Lance L

PY - 2006/8

Y1 - 2006/8

N2 - The role of mechanical strain and estrogen status in regulating ERalpha levels in bone cells was studied in female rats. OVX is associated with decreased ERalpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.

AB - The role of mechanical strain and estrogen status in regulating ERalpha levels in bone cells was studied in female rats. OVX is associated with decreased ERalpha protein expression/osteocyte, whereas habitual strain and artificial loading has only a small but positive effect, except on the ulna's medial surface, where artificial loading stimulates reversal of resorption to formation.

KW - Active Transport, Cell Nucleus

KW - Animals

KW - Cells, Cultured

KW - Estrogen Receptor alpha

KW - Estrogens

KW - Female

KW - Osteoblasts

KW - Osteocytes

KW - Ovariectomy

KW - Promoter Regions, Genetic

KW - RNA, Messenger

KW - Rats

KW - Rats, Sprague-Dawley

KW - Stress, Mechanical

KW - Tibia

KW - Ulna

U2 - 10.1359/jbmr.060504

DO - 10.1359/jbmr.060504

M3 - Article (Academic Journal)

C2 - 16869728

SN - 0884-0431

VL - 21

SP - 1297

EP - 1306

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 8

ER -

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

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