Outcomes and Resource Use of Sepsis-associated Stays by Presence on Admission, Severity, and Hospital Type

Stephen L Jones, Carol M Ashton, Lisa B Kiehne, Juan C Nicolas, Alexis L Rose, Beverly A Shirkey, Faisal Masud, Nelda P Wray

Research output: Contribution to journalArticle (Academic Journal)

Abstract

OBJECTIVE: To establish a baseline for the incidence of sepsis by severity and presence on admission in acute care hospital settings before implementation of a broad sepsis screening and response initiative.

METHODS: A retrospective cohort study using hospital discharge abstracts of 5672 patients, aged 18 years and above, with sepsis-associated stays between February 2012 and January 2013 at an academic medical center and 5 community hospitals in Texas.

RESULTS: Sepsis was present on admission in almost 85% of cases and acquired in-hospital in the remainder. The overall inpatient death rate was 17.2%, but was higher in hospital-acquired sepsis (38.6%, medical; 29.2%, surgical) and Stages 2 (17.6%) and 3 (36.4%) compared with Stage 1 (5.9%). Patients treated at the academic medical center had a higher death rate (22.5% vs. 15.1%, P<0.001) and were more costly ($68,050±184,541 vs. $19,498±31,506, P<0.001) versus community hospitals.

CONCLUSIONS: Greater emphasis is needed on public awareness of sepsis and the detection of sepsis in the prehospitalization and early hospitalization period. Hospital characteristics and case mix should be accounted for in cross-hospital comparisons of sepsis outcomes and costs.

Original languageEnglish
Pages (from-to)303-10
Number of pages8
JournalMedical Care
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Academic Medical Centers/economics
  • Adult
  • Aged
  • Aged, 80 and over
  • Community-Acquired Infections/economics
  • Costs and Cost Analysis
  • Cross Infection/economics
  • Diagnosis-Related Groups
  • Female
  • Hospitalization/economics
  • Hospitals, Community/economics
  • Humans
  • Length of Stay/economics
  • Male
  • Middle Aged
  • Patient Discharge/statistics & numerical data
  • Prevalence
  • Retrospective Studies
  • Sepsis/economics
  • Severity of Illness Index

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