Outside Back Cover: Solvent Channels and Electric Fields Guide Proton Delivery to the Active Site of Heme Peroxidases (Angew. Chem. 50/2025)

Local electric fields guide protons toward the heme through two distinct electrostatic funnels at the γ- and δ-edges in heme peroxidases. Water-mediated pathways enable proton exchange with key residues such as Arg38 and His42. These findings reveal that nature pre-organizes electrostatic funnels and solvent channels to provide multiple, well-defined routes for proton delivery, conserved across heme peroxidase enzymes. More in the Research Article (e202515743) by Reynier Suardíaz, Emma L. Raven, Adrian J. Mulholland, and co-workers.