Overcoming attenuation bias in regressions using polygenic indices

Hans van Kippersluis*, Pietro Biroli, Rita Pereira, Titus Galama, Stephanie von Hinke, S.F.W. Meddens, Dilnoza Muslimova, Eric Slob, Ronald de Vlaming, Niels Rietveld

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
Original languageEnglish
Article number4473
JournalNature Communications
Volume14
Issue number1
Early online date25 Jul 2023
DOIs
Publication statusE-pub ahead of print - 25 Jul 2023

Bibliographical note

Funding Information:
The authors gratefully acknowledge participants of the 23andMe, Inc. cohort for sharing GWAS summary statistics for educational attainment. This work made use of the Dutch national e-infrastructure with the support of the SURF Cooperative using grant no. EINF-2327. The authors also acknowledge funding from NORFACE through the Dynamic of Inequality across the Life Course (DIAL) program (462-16-100; H.v.K., P.B., S.v.H., C.A.R., S.F.W.M., D.M., R.D.P.), from the European Research Council (DONNI 851725 to S.v.H. and GEPSI 946647 to C.A.R.), from the National Institute on Aging of the National Institutes of Health (RF1055654, R56AG058726 to T.J.G., H.v.K. and R01AG078522 to T.J.G.), and from the Dutch Research Council (016.VIDI.185.044 to T.J.G.). H.v.K., P.B., T.J.G., S.v.H., and C.A.R. also acknowledge the European Union’s Horizon 2021 research and innovation program under the Marie Skłodowska-Curie grant agreement (ESSGN 101073237). This research was supported by the National Institute for Health Research (NIHR Cambridge BRC-1215-20014 for E.A.W.S.). The views expressed are those of the authors and not necessarily those of the National Institutes of Health, NIHR, or the Department of Health and Social Care. We would like to thank Sjoerd van Alten, Dan Belsky, Neil Davies, Ben Domingue, Michel Nivard, and Elliot Tucker-Drob for valuable comments.

Publisher Copyright:
© 2023, The Author(s).

Research Groups and Themes

  • ECON CEPS Health

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