Projects per year
Abstract
We report a Rh-catalyzed method for the C-5 selective C–H iodination of naphthoquinones and show that complementary C-2 selective processes can be achieved under related conditions. C–C bond forming derivatizations of the C-5 iodinated products provide a gateway to previously inaccessible A-ring analogues. The present study encompasses the first catalytic directed ortho-functionalizations of simple (non-bias) naphthoquinones. The strategic considerations outlined here are likely to be applicable to C–H functionalizations of other weakly coordinating and/or redox sensitive substrates.
Original language | English |
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Pages (from-to) | 3780-3784 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 7 |
Issue number | 6 |
Early online date | 2 Mar 2016 |
DOIs | |
Publication status | Published - 1 Jun 2016 |
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Dive into the research topics of 'Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C-H iodination as a gateway to functionalized derivatives'. Together they form a unique fingerprint.Projects
- 1 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research