Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

Emma E Vincent, Douglas J E Elder, Lois Phillips, Kate J Heesom, Joya Pawade, Michael Luckett, Mohammed Sohail, Margaret T May, Martin R Hetzel, Jeremy M Tavaré

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)

Abstract

Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. Patients and Methods: Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used. Results: Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p
Translated title of the contributionOverexpression of the TXNDC5 protein in non-small cell lung carcinoma
Original languageEnglish
Pages (from-to)1577 - 1582
Number of pages6
JournalAnticancer Research
Volume31
Issue number5
Publication statusPublished - May 2011

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