Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

Emma E Vincent; Douglas J E Elder; Lois Phillips; Kate J Heesom; Joya Pawade; Michael Luckett; Mohammed Sohail; Margaret T May; Martin R Hetzel; Jeremy M Tavaré

Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

Emma E Vincent, Douglas J E Elder, Lois Phillips, Kate J Heesom, Joya Pawade, Michael Luckett, Mohammed Sohail, Margaret T May, Martin R Hetzel, Jeremy M Tavaré

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Abstract

Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. Patients and Methods: Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used. Results: Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p

Translated title of the contribution	Overexpression of the TXNDC5 protein in non-small cell lung carcinoma
Original language	English
Pages (from-to)	1577 - 1582
Number of pages	6
Journal	Anticancer Research
Volume	31
Issue number	5
Publication status	Published - May 2011

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title = "Overexpression of the TXNDC5 protein in non-small cell lung carcinoma",

abstract = "Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. Patients and Methods: Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used. Results: Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p",

author = "Vincent, {Emma E} and Elder, {Douglas J E} and Lois Phillips and Heesom, {Kate J} and Joya Pawade and Michael Luckett and Mohammed Sohail and May, {Margaret T} and Hetzel, {Martin R} and Tavar{\'e}, {Jeremy M}",

note = "Other: Journal by subscription",

year = "2011",

month = may,

language = "English",

volume = "31",

pages = "1577 -- 1582",

journal = "Anticancer Research",

issn = "1791-7530",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

AU - Vincent, Emma E

AU - Elder, Douglas J E

AU - Phillips, Lois

AU - Heesom, Kate J

AU - Pawade, Joya

AU - Luckett, Michael

AU - Sohail, Mohammed

AU - May, Margaret T

AU - Hetzel, Martin R

AU - Tavaré, Jeremy M

N1 - Other: Journal by subscription

PY - 2011/5

Y1 - 2011/5

N2 - Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. Patients and Methods: Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used. Results: Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p

AB - Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. Patients and Methods: Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used. Results: Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p

M3 - Article (Academic Journal)

C2 - 21617212

SN - 1791-7530

VL - 31

SP - 1577

EP - 1582

JO - Anticancer Research

JF - Anticancer Research

IS - 5

ER -

Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

Abstract

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