Oxidative stress-related biomarkers in multiple sclerosis: a review

Richard Ibitoye, Kevin C Kemp, Claire M Rice, Kelly M Hares, Neil J Scolding, Alastair Wilkins

Research output: Contribution to journalArticle (Academic Journal)peer-review

44 Citations (Scopus)
864 Downloads (Pure)


AIM: To provide an up-to-date review of oxidative stress biomarkers in multiple sclerosis and thus identify candidate molecules with greatest promise as biomarkers of diagnosis, disease activity or prognosis.

METHOD: A semi-systematic literature search using PubMed and other databases.

RESULTS: Nitric oxide metabolites, superoxide dismutase, catalase, glutathione reductase, inducible nitric oxide synthase, protein carbonyl, 3-nitrotyrosine, isoprostanes, malondialdehyde and products of DNA oxidation have been identified across multiple studies as having promise as diagnostic, therapeutic or prognostic markers in MS.

CONCLUSION: Heterogeneity of study design, particularly patient selection, limits comparability across studies. Further cohort studies are needed, and we would recommend promising markers be incorporated into future clinical trials to prospectively validate their potential.
Original languageEnglish
Pages (from-to)889-902
Number of pages14
JournalBiomarkers in Medicine
Issue number8
Early online date14 Jul 2016
Publication statusPublished - Aug 2016


  • Biomarkers
  • Multiple Sclerosis
  • Oxidative Stress
  • Reactive oxygen species
  • Diagnosis
  • Disease activity
  • Disability progression
  • Therapeutic monitoring


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