TY - JOUR
T1 - Oxycodone for cancer-related pain
T2 - Meta-analysis of randomized controlled trials
AU - Reid, Colette M.
AU - Martin, Richard M.
AU - Sterne, Jonathan A C
AU - Davies, Andrew N.
AU - Hanks, Geoffrey W.
PY - 2006/4/24
Y1 - 2006/4/24
N2 - To evaluate the efficacy and tolerability of oxycodone in cancer-related pain, we conducted a systematic review of randomized controlled trials. Four studies, comparing oral oxycodone with either oral morphine (n=3) or oral hydromorphone (n=1), were suitable for meta-analysis. Standardized mean differences in pain scores comparing oxycodone with control groups were pooled using random-effects models. Overall, there was no evidence that mean pain scores differed between oxycodone and control drugs (pooled standardized mean difference, 0.04; 95% confidence interval [CI], -0.29 to 0.36; P=.8; I2=62%). In meta-regression analyses, pain scores were higher for oxycodone compared with morphine (0.20; 95% CI, -0.04 to 0.44) and lower compared with hydromorphone (-0.36; 95% CI, -0.71 to 0.00), although these effect sizes were small. The efficacy and tolerability of oxycodone are similar to morphine, supporting its use as an opioid for cancer-related pain.
AB - To evaluate the efficacy and tolerability of oxycodone in cancer-related pain, we conducted a systematic review of randomized controlled trials. Four studies, comparing oral oxycodone with either oral morphine (n=3) or oral hydromorphone (n=1), were suitable for meta-analysis. Standardized mean differences in pain scores comparing oxycodone with control groups were pooled using random-effects models. Overall, there was no evidence that mean pain scores differed between oxycodone and control drugs (pooled standardized mean difference, 0.04; 95% confidence interval [CI], -0.29 to 0.36; P=.8; I2=62%). In meta-regression analyses, pain scores were higher for oxycodone compared with morphine (0.20; 95% CI, -0.04 to 0.44) and lower compared with hydromorphone (-0.36; 95% CI, -0.71 to 0.00), although these effect sizes were small. The efficacy and tolerability of oxycodone are similar to morphine, supporting its use as an opioid for cancer-related pain.
UR - http://www.scopus.com/inward/record.url?scp=33646151412&partnerID=8YFLogxK
U2 - 10.1001/archinte.166.8.837
DO - 10.1001/archinte.166.8.837
M3 - Article (Academic Journal)
C2 - 16636208
AN - SCOPUS:33646151412
SN - 0003-9926
VL - 166
SP - 837
EP - 843
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 8
ER -