PAD4 controls chemoattractant production and neutrophil trafficking in malaria

Drinalda Cela, Sebastian Lorenz Knackstedt, Sarah J Groves, Christopher M Rice, Jamie Tae Wook Kwon, Benjamin Mordmüller, Borko Amulic*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)
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Peptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role in regulation of immune cell trafficking and chemokine production. PAD4 regulates liver immunopathology by promoting neutrophil trafficking in a Plasmodium chabaudi mouse malaria model. In human macrophages, PAD4 regulates expression of CXCL chemokines in response to stimulation with TLR ligands and P. falciparum. Using patient samples, we show that CXCL1 may be a biomarker for severe malaria. PAD4 inhibition promotes disease tolerance and may represent a therapeutic avenue in malaria.
Original languageEnglish
Pages (from-to)1235–1242
Number of pages8
JournalJournal of Leukocyte Biology
Issue number6
Early online date10 Nov 2021
Publication statusPublished - 1 Jun 2022


  • chemokine
  • malaria
  • neutrophil
  • PAD4


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