TY - JOUR
T1 - Paediatric pulmonary hypertension and sildenafil
T2 - current practice and controversies
AU - Wardle, A. J.
AU - Tulloh, R. M.
PY - 2013/8
Y1 - 2013/8
N2 - In recent times, paediatric pulmonary arterial hypertension management has been transformed to focus on disease modifying strategies that improve both quality of life and survival, rather than just symptom palliation. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this. Despite controversial beginnings, its success in treating pulmonary arterial hypertension has led to its consideration for related pathologies such as persistent pulmonary hypertension of the newborn and bronchopulmonary dysplasia, as well as the development of a range of alternative formulations. However, this has caused its own controversy and confusion regarding the use of sildenafil in younger patients. In addition, recent data regarding long-term mortality and the repeal of US drugs approval have complicated the issue. Despite such setbacks, sildenafil continues to be a major component of the contemporary care of paediatric pulmonary hypertension in a variety of contexts, and this does not seem likely to change in the foreseeable future.
AB - In recent times, paediatric pulmonary arterial hypertension management has been transformed to focus on disease modifying strategies that improve both quality of life and survival, rather than just symptom palliation. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this. Despite controversial beginnings, its success in treating pulmonary arterial hypertension has led to its consideration for related pathologies such as persistent pulmonary hypertension of the newborn and bronchopulmonary dysplasia, as well as the development of a range of alternative formulations. However, this has caused its own controversy and confusion regarding the use of sildenafil in younger patients. In addition, recent data regarding long-term mortality and the repeal of US drugs approval have complicated the issue. Despite such setbacks, sildenafil continues to be a major component of the contemporary care of paediatric pulmonary hypertension in a variety of contexts, and this does not seem likely to change in the foreseeable future.
UR - http://www.scopus.com/inward/record.url?scp=84894630218&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2013-303981
DO - 10.1136/archdischild-2013-303981
M3 - Article (Academic Journal)
C2 - 23771819
AN - SCOPUS:84894630218
VL - 98
SP - 141
EP - 147
JO - Archives of Disease in Childhood: Education and Practice Edition
JF - Archives of Disease in Childhood: Education and Practice Edition
SN - 1743-0585
IS - 4
ER -