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Palladium(II) trifluoroacetate (5 mol %) catalyzes the C-arylation of N,N-disubstituted hydantoins by aryl iodides in good yield. The reaction proceeds through base-promoted enolization of the amino acid derived hydantoins, and the resulting 5,5-disubstituted hydantoins may be deprotected at one or both N atoms to yield biologically active structures or alternatively hydrolyzed to the parent α-aryl α-amino acids. The reaction is successful with a variety of parent amino acids and a range of electron-rich and electron-poor aryl iodides.
|Number of pages||4|
|Early online date||22 Jul 2015|
|Publication status||Published - 7 Aug 2015|
FingerprintDive into the research topics of 'Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins'. Together they form a unique fingerprint.
- 1 Finished
alpha-Arylation and alpha-Vinylation of Enolates: New Reactivity from the Urea Linkage.
1/07/15 → 31/05/18