Projects per year
Abstract
We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to alpha,alpha-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.
Original language | English |
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Pages (from-to) | 1521-1523 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 49 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- KETONE O-PENTAFLUOROBENZOYLOXIMES
- HECK REACTIONS
- ENANTIOSELECTIVE SYNTHESIS
- AMMONIUM-SALTS
- DERIVATIVES
- REARRANGEMENT
- INSERTION
- ALKYNES
- PHOSPHORAMIDITES
- STEREOCENTERS
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Dive into the research topics of 'Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of alpha,alpha-disubstituted dihydropyrroles and studies towards an asymmetric protocol'. Together they form a unique fingerprint.Projects
- 2 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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New Transition Metal Catalysed Methods for Alkyl C-N Bond Formation
Bower, J. F. (Principal Investigator)
3/11/11 → 3/11/13
Project: Research