Palladium-Catalyzed ortho-Arylation of Carbamate-Protected Estrogens

Robin B Bedford; Peter B Brenner; Steven J Durrant; Timothy Gallagher; Carolina Méndez-Gálvez; Michelle Montgomery

doi:10.1021/acs.joc.6b00532

Palladium-Catalyzed ortho-Arylation of Carbamate-Protected Estrogens

Robin B Bedford, Peter B Brenner, Steven J Durrant, Timothy Gallagher, Carolina Méndez-Gálvez, Michelle Montgomery

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Abstract

The palladium-catalyzed ortho-arylation of diethylcarbamate-protected estrone and estriol with aryl iodides, gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol or estriol depending on the method used.

Original language	English
Pages (from-to)	3473–3478
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	81
Issue number	9
Early online date	8 Apr 2016
DOIs	https://doi.org/10.1021/acs.joc.6b00532
Publication status	Published - 6 May 2016

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3-month Core Capability for Chemistry Research
Crosby, J.
1/01/13 → 1/04/13
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Cite this

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abstract = "The palladium-catalyzed ortho-arylation of diethylcarbamate-protected estrone and estriol with aryl iodides, gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol or estriol depending on the method used.",

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AU - Montgomery, Michelle

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AB - The palladium-catalyzed ortho-arylation of diethylcarbamate-protected estrone and estriol with aryl iodides, gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol or estriol depending on the method used.

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Palladium-Catalyzed ortho-Arylation of Carbamate-Protected Estrogens

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