Palladium-Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (-)-alpha-Kainic Acid

Martin A. Lowe, Mehrnoosh Ostovar, Serena Ferrini, Chia-Chun Chen, Paul G. Lawrence, Francesco Fontana, Andrew A. Calabrese, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

89 Citations (Scopus)
Original languageEnglish
Pages (from-to)6370-6374
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number28
DOIs
Publication statusPublished - 2011

Keywords

  • annulation
  • aziridines
  • palladium
  • pyrrolidines
  • synthetic methods
  • EXCITATORY AMINO-ACIDS
  • CATALYZED CASCADE REACTIONS
  • CHIRAL LITHIUM AMIDES
  • IN-SITU GENERATION
  • (-)-KAINIC ACID
  • ACTIVATED OLEFINS
  • KAINIC ACID
  • 3+2 CYCLOADDITION
  • DIASTEREOSELECTIVE SYNTHESIS
  • ASYMMETRIC DEPROTONATION

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