Palladium(II) Catalyzed C–H Functionalization Cascades for the Diastereoselective Synthesis of Polyheterocycles

Michael Watt, Kevin Booker-Milburn

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)
222 Downloads (Pure)

Abstract

C−H activation offers huge potential in the generation of complex structures from simple starting materials. Herein we report the development of a highly diastereoselective palladium(II) catalyzed C−H functionalization cascade to produce novel, unsaturated polyheterocycles from simple diene-tethered heterocyclic starting materials. The reaction is applicable to both indole and pyrrole based substrates and tolerates a wide range of functional group substitutions around the heteroaromatic core. The polyheterocyclic products are formed as single diastereoisomers, with two new stereocenters formed in a single step.
Original languageEnglish
Pages (from-to)5716-5719
Number of pages4
JournalOrganic Letters
Volume18
Issue number21
DOIs
Publication statusPublished - 27 Oct 2016

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