PAMAM dendrimer - cell membrane interactions

Laura J Fox, Robert M Richardson, Wuge H Briscoe*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

146 Citations (Scopus)
650 Downloads (Pure)


PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e. size and surface group density), surface chemistry, and dosage, as well as cell specificity. In this review, biomedical applications of polyamidoamine (PAMAM) dendrimers and some related cytotoxicity studies are first outlined. Alongside these in vitro experiments, lipid membranes such as supported lipid bilayers (SLBs), liposomes, and Langmuir monolayers have been used as cell membrane models to study PAMAM dendrimer-membrane interactions. Related experimental and theoretical studies are summarized, and the physical insights from these studies are discussed to shed light on the fundamental understanding of PAMAM dendrimer-cell membrane interactions. We conclude with a summary of some questions that call for further investigations.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalAdvances in Colloid and Interface Science
Early online date27 Jun 2018
Publication statusPublished - Jul 2018


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